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Glutathione peroxidase uses glutathione reducing equivalents detoxifying peroxides

MEDI7247, an antibody-drug conjugate (ADC) that specifically binds to the extracellular domain of ASCT2, could release its payload pyrrolobenzodiazepine (PBD), promoting DNA damage and tumor cell death (Liu et al., 2018

This off-label combination has not been studied in clinical trials and could produce additive GI side effects similar to or exceeding those seen with CagriSema

In addition, although not meeting the level of statistical significance ( P = 006), there was a trend towards lower urinary 8-iso-PGF 2 in the test group